![]() ![]() Picrosirius red staining revealed extensive fibrosis in Mdr2 KO liver, and fibrosis colocalized with increased periportal inflammatory cells and both acrolein and 4-HNE staining. Identified carbonylated proteins were further evaluated using bioinformatics analyses. Concurrently, specific targets of carbonylation were assessed in LE prepared from murine groups as well as from normal and human patients with end-stage PSC. Using hepatic tissue and whole cell liver extracts (LE) isolated from 11-week old C57BL/6J (WT) and Mdr2 KO mice, inflammation and oxidative stress was assessed. ![]() The objective of this study was to elucidate the impact of cholestatic injury on oxidative stress-related factors. Cholangiopathies such as primary sclerosing cholangitis (PSC) are chronic liver diseases characterized by increased cholestasis, biliary inflammation and oxidative stress.
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